How Often Do You Get Prevnar 20

How Often Do You Get Prevnar 20 – Just one dose of Prevnar 20 helps protect against 20 strains of the bacteria that cause pneumococcal pneumonia — which can strike anytime, anywhere.

There are two types of pneumococcal vaccines – polysaccharides and conjugates. Prevnar 20 is a conjugate vaccine. Conjugate vaccines work by combining proteins with small pieces of inactivated pneumococcal bacteria to help activate the immune system. Your body is able to recognize bacteria without making you sick. This process helps your immune system make antibodies that help protect you against the 20 strains of bacteria that cause pneumococcal pneumonia.

How Often Do You Get Prevnar 20

Prevnar 20 helps protect against more strains of the bacteria that cause pneumococcal pneumonia than any other pneumococcal conjugate vaccine.

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You may already be doing a lot to protect your health, and here’s how to do even more.

If you’re 65 or older, or 19 or older with certain chronic conditions, you may be at greater risk for pneumococcal pneumonia—even if you feel healthy. Talk to your doctor or pharmacist to better understand your risk and ask if Prevnar 20 is right for you.

Prevnar 20 has been studied with chronic conditions including diabetes, kidney disorders, lung disease, liver disease, and heart disease.

If you’ve already had another pneumonia vaccine, ask your doctor or pharmacist if Prevnar 20 can help provide additional protection.

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Help protect yourself from pneumococcal pneumonia with just one visit to your doctor or pharmacist. Prevnar 20 is a one-time dose, so you don’t have to take it every year. ACIP Back Rex for New Pneumococcal Vax in Previously Immunized Adults — CDC advisories address the need to receive the 20-valent conjugate vaccine after PCV13.

CDC’s vaccine advisors updated their recommendations to clarify when to use the 20-valent conjugate pneumococcal vaccine (PCV20; Prevnar 20) in adults who previously received the 13-valent conjugate vaccine (PCV13; Prevnar 13).

In adults 65 years of age and older who completed a vaccination series with PCV13 and 23-valent polysaccharide vaccine (PPSV23; Pneumovax 23), the Advisory Committee on Immunization Practices (ACIP) voted 13-2. PCV20 should be given at least 5 years after the last dose of pneumococcal vaccine.

For people under 65 with certain underlying conditions or risk factors who have received both the PCV13 and PPSV23 vaccines but have not completed their full vaccination schedule, the ACIP voted 14-1 to recommend a dose of PCV20 at least 5 years after their last dose. to, or otherwise complete their vaccination series, as previously recommended by PPSV23.

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Finally, for individuals who had previously received PCV13 vaccination, the committee voted unanimously to recommend a dose of PCV20 at least 1 year later, or else PPSV23 as previously recommended, to complete their vaccination series.

Last year, the ACIP streamlined its recommendations for pneumococcal vaccination in adults who have not yet received the conjugate vaccine: All older adults, as well as younger adults with certain underlying medical conditions or risk factors, should receive one dose of PCV20, or else 15. -Valent PPSV23 followed by a conjugate vaccine (PCV15; Vaxneuvance).

With Thursday’s new recommendations, the committee addressed the use of PCV20 in adults with a vaccination history that includes PCV13.

Miwako Kobayashi, MD, MPH, lead of the ACIP Working Group for Pneumococcal Vaccines, explained that conjugate vaccines are expected to have a longer duration of protection than polysaccharide vaccines. Additionally, he noted in his presentation, “limited efficacy of PPSV23 has been reported in adults with immunocompromised conditions.”

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Not all ACIP members were in favor of shared decision-making on the new recommendation for adults age 65 and older, with Helen “Cape” Talbot, MD, of Vanderbilt University in Nashville, arguing to drop the language in favor of a full recommendation. . The amendment failed to receive enough votes (6 for, 9 against) for full recommendation, with cost considerations weighing on some members.

The CDC’s cost-effectiveness estimates suggested a range of $153,000 to $414,000 per quality-adjusted life year with the full recommendation, which would apply to about 17 million older adults, Kobayashi said.

ACIP member Beth Bell, MD, MPH, of the University of Washington in Seattle, said that while she sympathizes with wanting to save as many lives as possible, it’s still important to consider costs.

“I don’t think it’s a good idea to support something that involves … revaccinating a very large number of people for a very small incremental benefit,” Bell said.

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“Many older adults are still working,” she continued. “Some of them are at the table with us, and we want to keep them working because they have sharp minds and should be able to continue to contribute.”

Oliver Brooks, MD, of Watts Healthcare in Los Angeles, said he found the cost-effectiveness data “compelling,” but noted that the rate of pneumococcal disease is higher in African Americans with serotypes not covered by PCV13, and suggested that sharing Decision making was unlikely to benefit this group.

A sticking point for some committee members was the 5-year wait to administer PCV20 to younger adults (19 to 64) with certain underlying conditions or risk factors — such as an immunocompromising condition, cochlear implant, or cerebrospinal fluid leak. Both PCV13 and PPSV23 have yet to complete their full vaccination series.

Talbot argued for recommending a PCV20 dose after 1 year, noting that the efficacy of polysaccharide vaccines declines rapidly. Efficacy data presented at the two-day ACIP meeting suggested declines as early as 2 years with PPSV23, whereas no declines were observed with the conjugate vaccine over the first 5 years.

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ACIP member Camille Cotton, MD, of Massachusetts General Hospital in Boston, agreed, noting that 3% of the US population is immunocompromised and that this group has an 18-fold increased risk for invasive pneumococcal disease.

However, Sarah Long, MD, for children at St. Christopher’s Hospital in Philadelphia, said the work group found that a conjugate vaccine combined with PPSV23 allowed recipients to be “well protected for 5 years” and decided to give another dose soon after. The former would add “very little” benefit.

An amendment recommending a 1-year wait before PCV20 dosing in this population failed to pass by a vote of 2-13. ACIP supports 20-valent pneumococcal vaccine for children – new high-risk conditions also added, including chronic kidney disease. and asthma

The CDC’s Advisory Committee on Immunization Practices (ACIP) unanimously agreed Thursday to include the 20-valent pneumococcal conjugate vaccine (PCV20; Prevnar) for American children.

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ACIP also added new underlying conditions to the list of risk conditions: chronic kidney disease (except for dialysis patients, who are listed under immunologic conditions), chronic liver disease, moderate persistent or severe persistent asthma (under chronic lung disease), and those patients. Renal failure on maintenance dialysis.

“The current pneumococcal vaccines are a mess, and we’re trying to coordinate them a little bit with what’s already out there,” ACIP member Sarah Long, MD, of St. Christopher’s Hospital for Children in Philadelphia, explained before the vote. .

At the meeting, the CDC presented data showing a rate of invasive pneumococcal disease of more than 1.20 cases per 100,000 children under 5 in winter 2022, while rates from 2018 to 2021 were all less than 1 per 100,000.

“We don’t know when we’ll have severe weather like we have this season,” said Kathryn Poehling, MD, MPH, of Wake Forest School of Medicine in Winston-Salem, North Carolina, and chair of ACIP’s Working Group on Pneumococcal Vaccines. “This winter we’ve seen more cases of mastoiditis — which is a serious complication of ear infections and pneumonia that requires a chest tube — than I’ve seen in the last 20 years.”

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PCV20 provides the broadest serotype coverage of any PCV by adding serotypes 8, 10A, 11A, 12F, and 15B to the PCV15 vaccine. The FDA approved PCV20 for infants and children in April, with data supporting the approval in children ages 2 to 23 months based on randomized phase II and phase III data comparing the vaccine with PCV13.

In these children, PCV20 showed numerically lower immunoglobulin G geometric mean concentrations for 13 shared serotypes with PCV13. After the third dose, noninferiority for PCV20 versus PCV13 was not achieved for serotypes 1, 3, 4, 9V, 23F, and one of the 12F results. After the fourth dose, non-inferiority was achieved for all 13 common serotypes. Results also showed non-inferiority to PCV13 for seven additional non-shared serotypes.

For children aged 2 to 18 years with risk conditions, a single-arm phase III trial (involving healthy children who received three doses of PCV13) supported approval, showing that a single dose of PCV20 was immunogenic for all 20 subsequent serotypes. vaccine

Poehling expressed concern over the lack of clinical data for new vaccines: “I think it’s very important to remind everyone that we have all the immunogenicity data,” she said. “We have no efficacy and effectiveness data on PCV15 or PCV20.”

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Notably, she said, PCV15 has increased immunogenicity to serotype 3, “which is an important cause of pneumococcal disease today.”

There are multiple vaccine options, said Grace Lee, MD, MPH, ACIP president at Stanford University School of Medicine in California.